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An Overview of Pancytopenia
Indian Journal of Pathology and Microbiology (IJPM)
Malaria, caused mostly by Plasmodium falciparum and P. Antimalarial drug toxicity is one side of the risk-benefit equation and is viewed differently depending upon whether the clinical indication for drug administration is malaria treatment or prophylaxis. Drug toxicity must be acceptable to patients and cause less harm than the disease itself. Research that leads to drug registration tends to omit two important groups who are particularly vulnerable to malaria — very young children and pregnant women. Prescribing in pregnancy is a particular problem for clinicians because the risk-benefit ratio is often very unclear. The number of antimalarial drugs in use is very small. Despite its decreasing efficacy against P.
The disorder is characterized by bruising, fatigue , anemia , low blood platelet count and enlargement of the liver and spleen , and is caused by a hereditary deficiency of the enzyme glucocerebrosidase also known as glucosylceramidase , which acts on glucocerebroside. When the enzyme is defective, glucocerebroside accumulates, particularly in white blood cells and especially in macrophages mononuclear leukocytes. Glucocerebroside can collect in the spleen , liver , kidneys , lungs , brain , and bone marrow.
Current knowledge on Rickettsia felis infection in humans is based on sporadic case reports. Here we conducted a retrospective seroepidemiological survey of R. A total of patients with suspected rickettsioses presenting with fever of unknown origin FUO but tested negative for scrub typhus, murine typhus, or Q fever were retrospectively identified during to The archived serum samples were examined for the presence of antibodies against R.