In addition to tobacco and alcohol consumption, the two main risk factors for oral squamous cell carcinoma OSCC , recent studies have revealed infections with human papilloma virus HPV as an additional risk factor for OSCC development. While HPV infection is discussed as an independent risk factor in this region, its distinguished role in carcinogenesis of tumours localized to the oral cavity remains uncertain. A systematic literature search was performed using PubMed, Cochrane library, Science Direct, and the Internet search, with language restricted to English. P53 Tumour suppressor protein p53 has several functions that are related to maintaining genomic stability and inhibiting cell proliferation in response to DNA damage. For preventing neoplasia to occur, the most important of these functions are cessation of cell growth and induction of either apoptosis or senescence.
Lenovo ThinkPad P53 Review (Core i7-9850H, Quadro RTX 5000)
Role of p53 gene
In essence, a literature review identifies, evaluates and synthesises the relevant literature within a particular field of research. It illuminates how knowledge has evolved within the field, highlighting what has already been done, what is generally accepted, what is emerging and what is the current state of thinking on the topic. In addition, within research-based texts such as a Doctoral thesis, a literature review identifies a research gap i. However, your literature review does not need to be inclusive of every article and book that has been written on your topic because that will be too broad. Rather, it should include the key sources related to the main debates, trends and gaps in your research area. A review of literature presents much more than a summary of relevant sources. The act of reviewing involves evaluating individual sources as well as synthesising these sources in order to gain a broad view of the field.
p53-Mdm2 Interaction Inhibitors as Novel Nongenotoxic Anticancer Agents
DOI : Background: Cancer is a major global health problem with high mortality rate. Most of the clinically used anticancer agents induce apoptosis through genotoxic stress at various stages of cell cycle and activation of p
Metrics details. Malignant eccrine spiradenoma is one of the rarest sweat-gland tumors. Here, we describe a rare case of low grade malignant eccrine spiradenoma located at the vulva. The vulvar lesion was described as a mass measured 3.